PEA: Understand how the compound interacts with the endocannabinoid system

By Sechat editorial team

In recent years, a molecule present in our body has been gaining prominence in the health field and among scientists: palmitoylethanolamide (PEA). This bioactive compound, which is naturally produced in the human body, has shown a remarkable interaction with the endocannabinoid system (ECS), offering prospects for health improvements.

The endocannabinoid system is an important ally in regulating and balancing a series of physiological processes in the human body. This system is composed of endocannabinoids, receptors, and enzymes that are believed to help regulate a variety of functions in humans, including sleep, mood, memory, appetite, reproduction, and plays a role in communication between cells, regulating various functions, including pain control, inflammation, the immune system, and homeostasis (internal balance).

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Palmitoylethanolamide is synthesized on demand, and its production increases in situations of stress, injury, inflammation, and pain. Its role is to help maintain the body's balance, acting as an analgesic and anti-inflammatory, including in neuroinflammation. It can be found in nature in foods such as eggs, peanuts, and soybeans. According to Kali Nardino, Chief Marketing Officer of Endogen and a pharmacist specialized in wellness, the healthtech company focused on medicinal cannabis products and nutrition has developed a dietary supplement that aids in the body's balance, assisting in the modulation of the ECS.

 “The clinical use of PEA began in the 1960s, and several clinical studies have confirmed the pharmacological properties of this substance. In our portfolio, we have Curcuflan PEA II, which has an innovative and unprecedented formula in the national market as a form of supplementation and acts on the expanded endocannabinoid system.”

Additionally, this substance has also been prescribed for chronic pain, painful syndromes, and inflammatory processes, thus becoming a new therapeutic strategy. As research continues to unveil the secrets of palmitoylethanolamide, it becomes evident that this substance has the potential to offer solutions for a variety of health challenges.

“This nutrient is essential for the balance of our body, collaborating with the modulation of the endocannabinoid system. Although it does not require a prescription, we recommend that, for the use of PEA, it is important to consult a health professional, preferably a doctor or nutritionist, to receive appropriate guidance on dosage, duration of use, and management of medical or nutritional conditions related to each patient's situation,” emphasizes Nardino.