Full Spectrum Cannabidiol: Why the Complete Cannabis Formulation Improves Chronic Pain Treatment

Medicines based on medical cannabis are gaining ground in Brazil, especially among patients with chronic pain seeking more effective alternatives with fewer side effects. 

In this scenario, full spectrum cannabidiol emerges as a therapeutic alternative that combines various natural compounds from the plant — such as cannabinoids, terpenes, and flavonoids — capable of acting synergistically and enhancing clinical outcomes.

What Differentiates Full Spectrum in Pain Treatment
 

While products with isolated CBD undergo a purification process that removes other elements of the plant, full spectrum extracts retain cannabinoids, terpenes, and small concentrations of THC, within the limit allowed by Anvisa (up to 0.2%).

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This combination gives rise to the so-called entourage effect, a synergy between the compounds that enhances the therapeutic response.

Acting directly on the receptors of the endocannabinoid system, present in the central nervous system and responsible for regulating functions such as pain, mood, inflammation, and immunity, the complete formulation can help the body regain physiological balance.

Smaller Doses, More Tolerance, and Better Clinical Response

Studies indicate that patients tend to tolerate full spectrum extracts well, often needing smaller doses to achieve the same results as products with isolated CBD.

According to specialists, this difference is directly linked to the entourage effect, which enhances the joint action of the plant's compounds. To achieve the same therapeutic result, doses of full spectrum medications can be up to four times smaller than those of products with isolated CBD, which also helps reduce side effects such as postural hypotension, nausea, loss of appetite, and insomnia.

Cannabidiol has proven to be an important ally in managing chronic pain, such as that related to fibromyalgia, endometriosis, traumatic injuries, and persistent syndromes.

Dose Adjustment and Monitoring are Essential

Full spectrum extracts, due to containing THC, require even more care during the titration phase. The medical protocol includes:

• - conducting tests before starting treatment;
• - weekly monitoring during dose adjustment;
• - starting always with the lowest possible dose, gradually increasing.

The ideal dose can provide up to 80% improvement in symptoms. In some cases, after this milestone, it is possible to reduce or even suspend other medications over about three months.